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Bi CNU: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Bi CNU - General Information

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)

 

Pharmacology of Bi CNU

Bi CNU is one of the nitrosoureas indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in treatment of brain tumors, multiple myeloma, Hodgkin's disease, and non-Hodgkin's lymphomas. Although it is generally agreed that carmustine alkylates DNA and RNA, it is not cross resistant with other alkylators. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.

 

Bi CNU for patients

 

Bi CNU Interactions

No information provided.

 

Bi CNU Contraindications

BiCNU should not be given to individuals who have demonstrated a previous hypersensitivity to it.

 

Additional information about Bi CNU

Bi CNU Indication

For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.

Mechanism Of Action
Bi CNU causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Bi CNU also binds to and modifies (carbamoylates) glutathione reductase. This leads to cell death.
Generic Name
Carmustine
Synonyms
BCNU; Bischlorethylnitrosourea; Bischlorethylnitrosurea; Carmustin
Drug Category
Antineoplastic Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Carmustine
Becenun; Bi CNU; Carmubris; Gliadel; Gliadel Wafer; Nitrumon; BiCNU;
Absorption
5 to 28% bioavailability
Toxicity (Overdose)
The oral LD50s in rat and mouse are 20 mg/kg and 45 mg/kg, respectively. Side effects include leukopenia, thrombocytopenia, nausea. Toxic effects include pulmonary fibrosis (20-0%) and bone marrow toxicity.
Protein Binding
80%
Biotransformation
Hepatic and rapid with active metabolites. Metabolites may persist in the plasma for several days.
Half Life
15-30 minutes
Dosage Forms of Bi CNU
Powder, for solution Intravenous
Chemical IUPAC Name
1,3-bis(2-chloroethyl)-1-nitrosourea
Chemical Formula
C5H9Cl2N3O2
Organisms Affected
Humans and other mammals